Search center

Quick order
Product code:
Quantity:
Cross ReferenceHelp...
Please enter the product you want to cross reference
designGrignard reagentsdesignPrint this to PDF...Print...design
design

Organomagnesium halides of the general structure R-Mg-X, with R= Alkyl, alkenyl or Aryl and X= Halogen, are called Grignard reagents after their inventor. 

They are extremely valuable and widely used synthetic tools, mainly as carbanions in nucleophilic additions and substitution-reactions but also in a range of other transformations.

Grignard reagents are generally prepared by the reaction of an organic halide with metallic magnesium ('metallation') in dry diethyl ether or tetrahydrofuran.  In addition to metallation, numerous other methods for the preparation of Grignard reagents have been developed:

  • transmetallation of other organometallic compounds with anhydrous magnesium salts
  • sulfoxide/magnesium exchange
  • carbenoid-homologation
  • reaction with highly active magnesium
  • reaction with magnesium anthracene complex
  • iodine-magnesium exchange
  • exchange reaction using organo magnesium 'ate' complexes
  • transition metal-catalyzed Grignard formation
  • mercury-magnesium exchange

If you would like to receive this brochure, send your e-mail to info@acros.com, mentioning your complete address and write 'Grignard brochure' in the subject line.

design
designdesigndesign