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Derivatization reagents for gas chromatography and organic synthesis.

The protection of polar groups such as carboxylic acids, alcohols and amines with suitable reagents to produce non-polar derivatives, is of great interest in gaschromatography and in organic synthesis.  By changing the properties of a sample, it can be made more stable and easier to separate and detect by gaschromatography.  A suitable reagent should offer:

  • ease of reaction
  • quantitative reaction
  • reproducible yields and results
  • no side reactions
  • generation of a stable product
  • higher volatility of the derivative
  • lower detection limit
  • enabling of special detection methods (e.g. ECD for fluorine containing derivatives)

Alkylations, acylations and silylations are the most common reactions to derivatize a substrate.  Acros Organics is proud to bring you the following reagents commonly used for these derivatizations:

Code Acylation Code Alkylation / Esterification Code Silylation
16926 Heptafluorobutyric anhydride 98+% 38533 (Trimethylsilyl)diazomethane Tech., ca. 2.0M solution in hexanes 15646 (BSA) N,O-bis-(trimethylsilyl)acetamide 95%
21007 (MBTFA) N-methyl-bis(trifluoroacetamide) 98% 16125 N,N-dimethylformamide dimethyl acetal ca 97% 16800 (BSTFA) N,O-bis(trimethylsilyl)trifluoroacetamide 98+%
14712 Pentafluorobenzoylchloride 98% 38136 NEW Trimethylsulfonium hydroxide 16284 Chlorodimethylsilane 96%
13972 (TFA) Trifluoroacetic acid 99% 42053 Tetramethylammoniumhydroxide pentahydrate, 99% 12058 1,1,1,3,3,3-hexamethyldisilazane 98%
29381 (TFA) Trifluoroacetic acid, biochemical grade 38127 NEW N-methyl-N-(trimethylsilyl)heptafluorobutyramide
14633 Pentafluorobenzylbromide 22158 (MSTFA) N-methyl-N-(trimethylsilyl)trifluoroacetamide 97%
14781 Trifluoroacetic anhydride 22154 (MTBSTFA) N-(tert-butyldimethylsilyl-N-methyltrifluoroacetamide 98%
41693 Pentafluoropropionic anhydride 11012 Chlorotrimethylsilane 98%
H/0095 Heptafluorobutyryl imidazole 15569 (TMSDEA) N,N-diethyl-1,1,1-trimethylsilylamine 98%
37719 Trifluoroacetyl imidazole 16713 (TSIM) N-(trimethylsilyl)-imidazole 98%
14754 Hexafluoroisopropanol     21595 (MSA)     N-methyl-N-(trimethylsilyl)acetamide 98%
42202 Trimethylanilinium hydroxide
15890 Boron trifluoride dimethanol complex

 

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