| Functionalization of substrates using unsaturated organic peroxides In organic synthesis, radical reactions are commonly used for chain reactions (Giese, 1986). Radicals are used as synthetic intermediates in reactions which are often difficult to accomplish by other means and which can selectively occur under very mild conditions. The protection of functional groups, often essential for synthtic sequences of ionic reactions, is mostly not required for radical reactions (Curran e.a., 1996). Organic peroxides are well established synthetic agents as source for radicals in the manufacture of many pharmaceutical intermediates, herbicides, insecticides and various other fine chemicals. Using appropriate conditions for storage and handling of organic peroxides, potential hazards of run-away situations can be excluded and reactions are controlled and can be intrinsically safe (Akzo Nobel PC Product Catalogue; Swern, 170; Houben-Weyl, 1988). Because of the specific nature of radical chemical reactions, organic peroxides offer opportunities to reduce the number of reaction steps in synthetic routes, which would be needed applying classical synthetic procedures. In particular, introduction of functional groups can be achieved by using special organic peroxides.
Download the paper 'Functionalization of substrates using unsaturated organic peroxides' here Organic Peroxides in Radical Synthesis Reactions Peroxides and Azo-compounds available at Acros Organics: | 10515 | 2,2'-azobis(2-methylpropionitrile), 98% | | 17014 | tert-butyl peroxybenzoate, 98% | | 18034 | tert-butyl hydroperoxide, 70% solution in water | | 21178 | benzoyl peroxide, 75% remainder water | | 34974 | lauroyl peroxide, 99% | | 34975 | 2,2'-azobis(2-methylbutyronitrile), 98% | | 34977 | 1,1-di(tert-butylperoxy)-3,3,5-trimethylcyclohexane, 75% solution in aromatic free mineral spirit | | 34980 | 1,1-di(tert-butylperoxy)cyclohexane, 50% solution in aromatic free mineral spirit | | 34981 | tert-butyl peroxy-3,5,5-trimethylhexanoate, 97% | | 34983 | 2,2-di(tert-butylperoxy)butane, 50% solution in aromatic free mineral spirit | | 34984 | tert-butylperoxy isopropyl carbonate, 75% solution in aromatic free mineral spirit | | 34985 | tert-butylperoxy 2-ethylhexyl carbonate, 95% | | 34986 | tert-butyl peroxyacetate, 50% solution in aromatic free mineral spirit | | 34988 | dicumyl peroxide, 99% | | 34989 | di(tert-butylperoxyisopropyl)benzene, 96% | | 34990 | 2,5-dimethyl-2,5-di(tert-butylperoxy)hexane, 92% | | 34991 | tert-butyl cumyl peroxide, 94% | | 34993 | di-tert-butyl peroxide, 99% | | 34994 | 3,6,9-triethyl-3,6,9-trimethyl-1,4,7-triperoxynonane, 41% solution in aromatic free mineral spirit | | 34996 | cumyl hydroperoxide, 80% | | 34997 | 3,4-dimethyl-3,4-diphenylhexane, 98% | | 34998 | 2,3-dimethyl-2,3-diphenylbutane, 95% | | 37855 | tert-butylperoxy allyl carbonate, 70 wt.% solution in odourless mineral spirit | | 37856 | allyl cumyl peroxide, 70-80 wt.% solution in 2-phenylisopropanol | | 37857 | tert-butyl monoperoxymaleate, 25 wt.% paste in dibutyl maleate | | 37858 | 2,4,6-tris(t-butylperoxy)-1,3,5-triazine, 35 wt.% in toluene/bis(2-ethylhexyl)adipate | | 37859 | 2,2-di(4,4-di(tert-butylperoxy)cyclohexyl)propane, 20 wt.% solution in ethylbenzene |
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