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designDerivatization for GCdesignPrint this to

Derivatization reagents for gas chromatography and organic synthesis.

The protection of polar groups such as carboxylic acids, alcohols and amines with suitable reagents to produce non-polar derivatives, is of great interest in gaschromatography and in organic synthesis.  By changing the properties of a sample, it can be made more stable and easier to separate and detect by gaschromatography.  A suitable reagent should offer:

  • ease of reaction
  • quantitative reaction
  • reproducible yields and results
  • no side reactions
  • generation of a stable product
  • higher volatility of the derivative
  • lower detection limit
  • enabling of special detection methods (e.g. ECD for fluorine containing derivatives)

Alkylations, acylations and silylations are the most common reactions to derivatize a substrate.  Acros Organics is proud to bring you the following reagents commonly used for these derivatizations:

Code Acylation Code Alkylation / Esterification Code Silylation
16926 Heptafluorobutyric anhydride 98+% 38533 (Trimethylsilyl)diazomethane Tech., ca. 2.0M solution in hexanes 15646 (BSA) N,O-bis-(trimethylsilyl)acetamide 95%
21007 (MBTFA) N-methyl-bis(trifluoroacetamide) 98% 16125 N,N-dimethylformamide dimethyl acetal ca 97% 16800 (BSTFA) N,O-bis(trimethylsilyl)trifluoroacetamide 98+%
14712 Pentafluorobenzoylchloride 98% 38136 NEW Trimethylsulfonium hydroxide 16284 Chlorodimethylsilane 96%
13972 (TFA) Trifluoroacetic acid 99% 42053 Tetramethylammoniumhydroxide pentahydrate, 99% 12058 1,1,1,3,3,3-hexamethyldisilazane 98%
29381 (TFA) Trifluoroacetic acid, biochemical grade 38127 NEW N-methyl-N-(trimethylsilyl)heptafluorobutyramide
14633 Pentafluorobenzylbromide 22158 (MSTFA) N-methyl-N-(trimethylsilyl)trifluoroacetamide 97%
14781 Trifluoroacetic anhydride 22154 (MTBSTFA) N-(tert-butyldimethylsilyl-N-methyltrifluoroacetamide 98%
41693 Pentafluoropropionic anhydride 11012 Chlorotrimethylsilane 98%
H/0095 Heptafluorobutyryl imidazole 15569 (TMSDEA) N,N-diethyl-1,1,1-trimethylsilylamine 98%
37719 Trifluoroacetyl imidazole 16713 (TSIM) N-(trimethylsilyl)-imidazole 98%
14754 Hexafluoroisopropanol     21595 (MSA)     N-methyl-N-(trimethylsilyl)acetamide 98%
42202 Trimethylanilinium hydroxide
15890 Boron trifluoride dimethanol complex